micro- gram +

Strep.pyogenes diseases

strep throat
scarlet fever
rhematic fever
post-strep glomerulonephritis

strep.pyogenes characteristics

group A (lancefield angtigen A) Beta-hemolytic (completely lyse rbcs = clear zone)
M protein: inhibits activation of complement/prevents phagocytosis (but Ab's detect)
Streptolysin O: Oxygen labile (reason for ASO Abs)
pyrogenic exotoxin: rare, erythrog

Rx of streptococcal pharyngitis

penicillin

Rx of skin infections caused by group A beta-hemolytic streptococci

must also cover staph.aureus!
penicillinase resitant pen like dicloxacillin

Rx of Necrotizing Fasciitis

Pen G (strep.pyogenes still very susceptible) + clindamycin (to stop metabolism and toxin produciton)
(Mortality still > 50%)

Empiric Ab's for suspected meningitis in a neonate should cover what 3 bugs

E.coli
Listeria monocytogenes
Group B (strep pyogenes)

in the 'free window' when infants are relatively antibody depleted (6mo-2yrs) what bugs should be considered

Neisseria meningitidis
Haemophilus influenza

Petechial rash, spiking fever, chills, arthralgia is a protypical presentation of:

meningococcemia