Cancer

hyperpolarize

BraC1
LOI

Gene amplification

HER-2
C-NYMC

Loss of Heterozyg

Rb

Tumor Suppesor Downregulator

BAD
CDKn1b

Deletion

PTEN

Oncogen overexpression

Cyclin D1
MDM2

Gain of Function (always active)

c-neu
RAS

Loss of Function

p53
VHL

Viral

V-SRC

E6 & e7

VEGFR

Angiogensis
w/ HIF1a activation

Motility

RhoA, RaCl, CDC42

Metastisis

MMP2
MMP9

Downregulation of metatistis prevention

E-Cadherin

Chomosomal Transloation

BRC/ABL

Drug-Imatinib (Gleevec®)

BRC/ABL

Drug-rapamycin (Sirolimus)

mtorc1

drug-Trastuzumab (Herceptin)

HEr-2

drug-Bevacizumab (Avastin)

vegfr