GI/GU Cancer; Breast Ca

Tumor marker for yolk sac (endodermal sinus tumor)

AFP

Most common ovarian germ cell tumor?

Mature teratoma

Dysgerminoma (sheets of unifrom cells) tumor marker

hCG

Meig's syndrome

Triad of ovarian fibroma, ascites, hydrothorax

Call-exner bodies

Granulosa cell tumor (secrete E) - small follicles filled w/ eosinophilic secretions

Pseudomyxoma peritonei

intraperitoneal accumulation of mucinous material form ovarian or appendiceal tumor (multiple tumors)

Serous cystadenocarcinoma

50% of ovarian tumors, malignant and often bilateral

Krukenberg tumor

GI malignancy that mets to ovaries = signet ring adenocarcinoma

Exposure to diethylstilbestrol

clear cell adenocarcinoma of the vagina

sarcoma botryoides (rhabdomyosarcoma vriant)

girls < 4 yo, spindle shaped tumor cells are desmin +, look like grapes protruding from the vagina

The most common testicular germ cell tumor, characteristics

seminoma
('fried egg', radiosensitive, younger males, painless, excellent px)

Endodermal sinus tumor (aka infantile yolk sac tumor)

analogous to ovarian (meaning AFP is marker)
*schiller-duval bodies pathognomonic: primitive glomeruli
*assoc w/ alpha1 antitrypsin

Reinke crystals

hollow tube-like structures
found in leydig cell testicular (non germ cell) tumors - usually adnrogen producing (gynecomastia or precocious puberty)

Most common testicular cancer in older men?

testicular lymphoma

Doc, I've got a bag of worms in my sac!

varicocele - dilated vein in pampniform plexus

can cuase infertility

Erythroplasia of Queyrat

red velvet plaques, usually on glands - similar to Bowen's disease (skin neoplasm)

Bowenoid papulosis

multiple papular lesions, youngin's usualy, doesn't invade

Bowen's dx

gray, solitary crusty plaque - usually on shaft or scrotum; peak in 5th decade, px to invasive SCC < 10%

Peyronie's dx

bent penis due to acquired fibrous tissue formaiton

Paget's dx of the breast

Paget cell = large cells w/ halo

eczematous patches on nipple - suggests underlying Ca

Fibroadenoma

most common tumor < 25 yo
small, mobile mass w/ increased size/tenderness w/ preg
not a precursor to breast ca

Phyllodes tumor

large, bulky mass of ct and cyts.
may have 'leaflike' projections
malignant type: cystosarcoma phyllodes

Most important px factor in breast ca?

axillary lymph node involvement

Invasive lobular carcinoma

often multiple, bilateral, and ordelry rows of cells

most common breast carcinoma (75%)

invasive ductal, NOS = firm, fibrous mass -worst px

Intraductal papilloma

benign tumor of lactiferous ducts that must be dist. from carcinoma

*presents w/ serous or bloody discharge