L22: Just the Receptors

increases intracellular calcium

a-1 & M3

if activated, leads to vasoconstriction of arterioles

a-1 & a-2

location: arterioles & cardiac muscle

a-1

location: arterioles

a-1, a-2, B-2, & M3

if activated, increases contractility

a-1, B-1, B-2

if activated, leads to activation of adenylyl cyclase and increase in cAMP

B-1 & B-2

if activated, leads to inhibition of adenylyl cylase and reduction of cAMP

a-2 & M2

location: Purkinji system

B-1 & B-2

location: SAN & AVN

B-1, B-2 & M2

dilates arterioles

B-2 & M3

decreases contractility via NO

B-3

a-1 receptors _____ intracellular Ca

increase

a-2 receptors _____ adenylyl cyclase

inhibit

B-1 receptors _____ adenylyl cyclase and _____ cAMP

activate, increase

B-2 receptors _____ adenylyl cyclase and _____ cAMP

activate, increase

B3 receptors _____ NO synthase and _____ the cGMP pathway

activate, stimulate

M2 receptors _____ adenylyl cyclases and _____ cAMP

inhibit, reduce

M2 receptors _____ K channels

activate

M2 receptors _____ guanylyl cyclase and _____cGMP

activate, increase

M3 receptors _____ Ca and subsequently _____NO synthase

increase, activate