Anti-cancer drugs Two Star

cytarabine

antimetabolite ;DOC for AML; MOA :-blocks DNA strand elongation;neurotoxic

capecitabine

Oral prodrug, converted to 5-fluorouracil. It inhibits thymidylate synthase (DNA SYN stopped). Useful for paclitaxel and doxorubicin - resistant patients with colorectal or metastatic breast cancers
NEW DRUG FOR PANCREATIC CANCER

carmustine

alkylating agent - toxic to the CNS-used for CNS cancers

etoposide

Stabilizes the topoisomerase II-DNA complex causing double strand DNA breaks during DNA replication. Dose limiting leukopenia. Treats first time, and metastatic testicular cancer

topotecan

UniqueTopoisomerase 1 inhibitor, preventing religation of bits of helices; causes accumulation of single stranded breaks in DNA. Dose -limiting neutropenia

fulvestrant

Antiestrogen for hormone-sensitive tumors

flutamide/finasteride

Nonsteroidal androgen antagonist (NSAA )which inhibits the translocation of steroid receptors to the nucleus . 5-alpha reductase inhibitor-inhibits synthesis of dihydrotestosterone .Both used to treat prostate cancer.

leuprolide

GnRH analogues which acts as a partial agonists at GnRH receptors. When administered in constant doses to maintain stable blood levels, it inhibit the release of LH and FSH. Used in the treatment of prostate cancer .

rituximab

This is an unconjugated chimeric(murine/human)antiCD20 monoclonal antibody which binds to the CD20 antigen on follicular B cells in Non Hodgkins lymphoma

Hydroxyurea

Inhibits ribonucleotide reductase ; stops conversion of ribonucleotides to deoxyribonucleotides.;for myeloproliferative disorders

imatinib mesylate

Inhibits bcr-abl tyrosine kinase found in chronic myelocytic leukemia(CML).

dactinomycin

binds to DNA and inhibits DNA dependent RNA synthesis
CCNS -

1. Rhabdomyosarcoma 2. Wilm’s tumor in children 3. Ewing’s tumor 4. Kaposi’s sarcoma

Hematopoietic suppression Pancytopenia-dose limiting

daunorubicin

Cytotoxic antibiotics, CCNS
LEUKEMIA, red urine

temozolamide

CCNS - alkylating agent
success in treating malignant gliomas

Glioblastoma multiforme is considered incurable