anti-protozal

prophylaxis (malaria)

chloroquine - non-resistant
mefloquine - resistant
doxycyline - multidrug resistant
primaquine - relapse of P. vivax/ovale

threrapy (malaria)

quinindine/quinine - severe infection
uncomplicated infection - chloroquine
chloroquine resist - mefloquine
prev of relapse - p. vivax/ovale

amebiasis

luminal - idoquinol(large bowl)/paromycin
systemic - choloquine
mixed - metronidazole

therapy (amebiasis)

asymp intest - iodoquinol/paromycin
mild to severe - metronidazole (+luminal agent)
ameboma/extraintest - metroidzole
hepatic abcscess - met + chloro

MOA - chloroquine

inhibits free heme to hemozin

MOA - pyrimethamine

inhib DHF reductase, works in the liver

moa - doxycycline

prev acesss tRNA to A site of Ribro
(no protein synthesis)

primaquine

hypnozoite
need a nml G6PD level
good for liver stage

cloraquine

good use, not good for LIVER schizoids

quinidine

hypnozoite
need a nml G6PD level
could lead to hypertension

babesiosis

quinine + clindamycin
B. microti

mefloquin

resistant malaria
..causes pyschosis, conufsions, seizures

metronidazole

giadiasis or trichomoniasis
free radical formation