immunoSTIM

levamisole

anti-parasitic, stimulates T cell
use with colon cancer
adverse - neutropenia

BCG

- nonspec stim
use - theraphy of bladder cancer

cytokines-group 1

interferons
a,b,g
A = Class 1 MHC, less MCH2
hairy cell luek

B = MS
G = granulomatous disease, act phago

cytokines-group 2

interlukins
Aldeslukein - promote lymphoid to cytotoxic and NK cells
- serious CVS tox (leakage, hypoten)

Oprelvekin - IL-11....platelet formation,
thombocytopenia

cytokines-group 3

Colony Stim Factors
1. filgrastim - increase granulocytes CFu-G - neutrophils
BM recovery during chemo

2. Sargramostim - GM-CSF...stimultate granulocity and macrophage
myloid recevory

neutropeia with AIDS
-contraindic = wtih heart F, edema, yeast hyper

3. Epoetin-alpha + Fe
treat aniema assoc wtih AIDS, chemo

4. thrombopoetin - same as erythropotein, stimulate megakaryocytes
a. recombo human - aneimna
b. recomobon fusion pro - plate rec