Neoplasia - genetics

growth factors

SIS (PDGFB)

growth Receptors

HER (erbB2) & ret

signal transduction

ras & ABL

nuclear transctiption

myc & N-myc

SIS

OE - astrocytoma/glioblastoma

HER/NEU (erbB2)

Amp - ductal Breast/ovarian

RET

point - Thyroid (MEN2A)

RAS

PT -colon/pancreas/lung/AML
GTP-Binding

ABL

9-22T (philly) (Bcr-Abl)
CML, Acute Lymp Luek
non-receptor tyrosine kinase

myc

8-14T - Brukitt lymphoma

N-myc

Amp - neuroblast, small cell CA

Acute pro-mye Luek

15-17T
RAR—PML fusion product results in a maturation arrest of granulocytes at pro-myelocytic stage

TSG- nuclear transcption

APC - polyps
Down regulates B-Cantine (Nml)

TSG - DNA repair

BRAC1/2 - Breast, ovary, prostate

TSG - G1-S phase

RB - RB, ostogeninic sarcoma, breast

Binds to EF2 (when Rb is hypophos)

HPV - E7

TSG - G1-s

TGF-B - pancreatic/colorectal

cyclin D

first cyclin to increase in cell cycle

TSG - G-1S, DNA repiar, BAX (BLC2) (apoptoisis)

P53 - lung, Li-fraumeni, colon/breast

acts via p21 (cyclin inhibition)

HPV - E6

TSG - nuclear transcription

VHL - von hippel
hemangioblastomas of CNS, retinal angiomas, renal cysts

TSG - reg nuclear transcription

Wt-1 - Wilm's tumor

PTEN

endometial carinomas

INK4a/ARF

Familial Melanomas

NF-1/NF2

RAS, GTPase..

Anti-apoptosis - BCL-2

14-18T
follicular lymphoma, most common
can't destory B lymphocytes

HNPCC

mismatch-repiar
MSH2/ MLH1

Xerderma pigmentosa

multiple skin cancers
DNA repair damange due to UV light

BRAC1/Brac2

B1 familial breast + ovaian cancer
B2 - ovarian cancer

Angiogensis

VEGF, bFGF

Metastasis 4 steps

1. Detachment from ea other - (loss of E-cad)
2. attachment to matrix - inceased laminin
3. Degrade ECM - proteases (collengenase)
4. Migration - cytokines

Warburg

use glycolysis insted of ox-pos

miRNAS

control cell growth, non-coding SSRNA